用 κ-carrageenan 涂层的磁性基烯基甲基纤维素/奇托桑纳米颗粒作为 pH 敏感的纳米载体,以有效释放甲醇
Hessam Jafari1, Hassan Namazi2
1Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
International journal of biological macromolecules
|August 12, 2025
概括
开发了磁性基烯基甲基纤维素/奇托桑/κ-卡拉基南纳米颗粒,用于向的甲特雷克萨特输送. 这些生物相容的纳米颗粒显示了pH敏感的药物释放和对乳腺癌细胞的增强细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 控制药物释放系统对于向治疗至关重要.
- 基于聚合物的纳米粒子为增强药物输送提供了潜力.
- 交联聚合物可以提高纳米粒子稳定性和药物封装.
研究的目的:
- 设计和表征磁性基甲基纤维素 (mHPMC) /奇托 (Chito) /κ-carrageenan (κ-Car) 纳米颗粒,用于控制和向的甲状腺酸盐 (MTX) 释放.
- 评估开发的纳米粒子的物理化学性质,药物负载,体外释放动力学和生物相容性.
- 评估MTX载入纳米颗粒对乳腺癌细胞的抗癌疗效.
主要方法:
- 通过mHPMC,Chito和k-Car的交叉链接进行纳米粒子合成.
- 使用FE-SEM/EDS,TGA,FT-IR,TEM,泽塔电位和XRD进行表征.
- 在不同pH值 (5.5和7.4) 的体外药物释放研究.
- 在MDA-MB 231乳腺癌细胞上的体外细胞毒性测试 (MTT测试).
- 生物相容性评估包括血液溶解,抗氧化活性和酶降解.
主要成果:
- 成功合成了大约50±5nm大小的mHPMC-Chito/κ-Car纳米粒子.
- 实现了高的MTX封装效率,从71.8%到89.4%不等.
- 经证实pH敏感的MTX释放,pH7.4的释放率较低,而pH5.5的释放率较低.
- 确认了纳米颗粒的良好的生物相容性,血液相容性,抗氧化特性和生物降解性.
- 观察到MTX载荷纳米颗粒对MDA-MB 231乳腺癌细胞的增强细胞毒性.
结论:
- 开发的mHPMC-Chito/κ-Car纳米粒子是有效的载体,可以控制和准MTX输送.
- 这些纳米粒子表现出有利的物理化学特性,生物相容性和抗癌活性.
- 这些纳米颗粒具有在癌症治疗和生物医学中应用的巨大潜力.
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