解码OSCC预测:洞察与年龄相关的模式和生存动态使用AJCC第八版和CAP协议
Dr Sandhya Sundar1, Dr Suganya Paneerseelvam1, Dr Pratibha Ramani1
1Dept. of Oral Pathology and microbiology, Saveetha Dental College & Hospitals, Saveetha institute of medical and technical sciences, Chennai 600077, Tamilnadu, India..
Journal of stomatology, oral and maxillofacial surgery
|August 12, 2025
概括
这项关于口腔状细胞癌 (OSCC) 的研究发现,虽然老年患者往往患有晚期疾病,但入侵深度和淋巴结状况是 stadium 比年龄更强的预测因素. 基于风险的个性化管理对OSCC至关重要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 口腔状细胞癌 (OSCC) 是一种流行的口腔癌,发病率越来越高.
- 了解临床病理特征和预后因素对于有效的患者管理至关重要.
研究的目的:
- 探索OSCC患者的临床病理特征和无病生存期 (DFS).
- 调查OSCC中与年龄相关的预后差异.
- 确定OSCC中晚期疾病阶段的独立预测因素.
主要方法:
- 对2022年诊断的OSCC病例的回顾性分析.
- 利用了美国病理学家学院 (CAP) 协议和AJCC第八版演出.
- 患者之间的临床病理学参数比较≤50年和>50年.
主要成果:
- 老年患者 (>50岁) 更频繁地呈现了晚期III/IV阶段的疾病,并且淋巴结参与率和邻近结构入侵率更高.
- 年轻患者的II期癌症比例更高,平均入侵深度 (DOI) 更高.
- 侵入深度 (DOI) 和淋巴结状况被确定为多变量分析中高级阶段的独立预测因素,而年龄失去了统计意义.
结论:
- 侵袭的深度和淋巴结状况是口腔状细胞癌晚期的更强的独立预测因素,而不是患者年龄.
- 尽管年龄与疾病程度有相关性,但个性化,基于风险的管理策略对于OSCC至关重要.
- 这些发现支持在OSCC分期和治疗规划中对DOI和节点状态进行集中评估的需要.
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