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Updated: Sep 11, 2025

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LGR5/mTORC2轴调节细胞代谢可塑性,以维持肝细胞癌的瘤发生

Guishuai Lv1, Qianni Zong2, Liang Wang2

  • 1International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Naval Medical University (Second Military Medical University), Shanghai 200438, China; National Center for Liver Cancer, Naval Medical University (Second Military Medical University), Shanghai 201805, China; Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Shanghai 200438, China; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education, Shanghai 200438, China.

Cancer letters
|August 12, 2025
PubMed
概括

肝癌干细胞 (LCSCs) 使用LGR5来增强糖解和生存代谢压力. 甲胺向这种LGR5驱动的代谢脆弱性,为肝细胞癌 (HCC) 提供了潜在的治疗策略.

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