虫感染会影响宿主对病毒感染和疫苗的免疫反应
Juan García-Bernalt Diego1,2,3, Pritesh Desai4, Stephen T Yeung5
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
FEMS microbiology reviews
|August 12, 2025
概括
虫感染可以改变对病毒和疫苗的免疫反应. 本综述探讨了虫如何调节抗病毒免疫力和疫苗疗效,影响宿主健康.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 虫感染在全球普遍存在,并且长期存在.
- 这些寄生虫是强大的免疫调节剂,影响宿主免疫反应.
- 虫诱导的免疫调节可以影响对病毒和疫苗等无关抗原的反应.
研究的目的:
- 审查共感染期间虫和病毒之间的复杂相互作用.
- 检查虫感染对抗病毒疫苗疗效的影响.
- 描述参与介导免疫调节的机制和免疫作用者.
主要方法:
- 对临床前模型和人体试验的文献综述.
- 对虫病毒共感染的免疫反应的分析.
- 免疫调节机制的表征.
主要成果:
- 虫显著调节宿主免疫反应.
- 这些调制可以损害或歪曲对病毒感染和疫苗的免疫反应.
- 时间,遗传学和环境等因素会影响共感染的结果.
结论:
- 虫共感染带来了复杂的免疫挑战.
- 了解虫病毒与疫苗的相互作用对于公共卫生至关重要.
- 需要进一步的研究来充分阐明这些相互作用及其影响.
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