绝经后骨质疏松症免疫调节疗法的研究趋势:一个图书法分析分析
Wen Tang1, Shenghui Yi1, Janguo Liu1
1Spinal Orthopedics, Yueyang Hospital of Traditional Chinese Medicine, Yueyang, China.
Orthopaedic surgery
|August 12, 2025
概括
免疫调节疗法对绝经后骨质疏松症有希望,研究重点关注RANKL/RANK/OPG和T细胞炎症等途径. 新兴领域包括肠道微生物群-骨轴和干细胞疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 绝经后的骨质疏松症是一个重大的健康问题.
- 免疫调节疗法提供了新的治疗途径.
- 了解研究趋势对于推进治疗策略至关重要.
研究的目的:
- 对2000年至2024年期间的绝经后骨质疏松症免疫调节疗法研究进行文献分析.
- 确定该领域的出版动态,协作网络和主题演变.
- 突出重点研究热点和新兴主题.
主要方法:
- 来自Web of Science核心集合 (2000-2024) 的950篇文章的图书统计分析.
- 使用CiteSpace,VOSviewer和基于R的Bibliometrix进行数据分析.
- 检查了出版趋势,国际合作和关键词的演变.
主要成果:
- 年度出版物显示稳步增加,在2024年达到顶峰.
- 中国和美国是主要的贡献者.
- 关键的研究领域包括RANKL/RANK/OPG通路,T细胞炎症 (Th17/IL-17轴),肠道微生物群-骨轴和干细胞分化.
- 代诺苏马布 (抗RANKL) 和IL-17抑制剂是优先考虑的临床策略.
- 存在着重要的国际机构合作.
- 研究重点转向基因编辑和精密医学.
结论:
- 免疫疗法在治疗绝经后骨质疏松症方面具有变革性的潜力.
- 需要进一步的研究来验证当前临床策略的长期安全性.
- 建议多学科整合,扩展数据源和严格的临床验证.
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