卵细胞冷保存的结果:基于年龄和治疗指示的分析
Michal Kirshenbaum1,2, Catharyn Stern1,2, Petra Wale3
1Reproductive Services Unit, Royal Women's Hospital, Melbourne, VIC, Australia.
Human reproduction (Oxford, England)
|August 12, 2025
概括
卵细胞冷保存 (OC) 的年龄较小显著提高每周期累积活产率 (CLBR). 虽然癌症等治疗指示在CLBR中没有显示统计学上显著的差异,但早期的OC对于最大限度地提高生育保护成功至关重要.
科学领域:
- 生殖医学 生殖医学
- 保护生育能力 保护生育能力
- 卵细胞冷保存的结果
背景情况:
- 卵细胞冷保存 (OC) 是一种关键的生育保存方法,其成功严重取决于结时的女性年龄.
- 关于不同医疗和选择性适应症如何影响OC周期结果的数据有限.
研究的目的:
- 调查卵细胞冷保存 (OC) 和治疗指示对OC周期结果的年龄的影响.
- 确定对每个温暖周期累积活产率 (CLBR) 的影响.
主要方法:
- 在墨尔本试管婴儿中,对3164名女性 (2014-2023) 进行了4577个OC周期的回顾性队列研究.
- 循环按卵细胞采集时的年龄分类,并说明:癌症,其他医疗或非医疗.
- 主要结局:每个温暖周期的CLBR;次要结局包括卵细胞存活率,受精率和怀孕率.
主要成果:
- 较年轻的OC年龄与较高的CLBR显著相关;35岁以下的患者有49.0%的CLBR,而40岁以上的患者有17.2%.
- 与其他组 (85.3%-83.3%) 相比,癌症组的卵细胞存活率较低 (81.5%).
- 在癌症,其他医疗和非医疗适应症 (P > 0.05) 之间没有观察到CLBR的统计学上显著差异.
结论:
- 卵子冷保存的年龄是最大化累积活产率的关键因素.
- 对于癌症患者来说,OC仍然是一个可行的生育保护选择,尽管卵细胞存活率略低.
- 需要进一步的研究来探索特定的癌症类型和治疗对卵细胞质量和结果的影响.
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