相关实验视频
Updated: Sep 11, 2025

13:10
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
7.4K
自然抗氧化剂作为循环RNA表达和功能的调节剂
Aseela Fathima1, Shadiya Fawzu Ameer1, Rabia Ilhem Kerzabi1
1Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Wiley interdisciplinary reviews. RNA
|August 12, 2025
概括
自然抗氧化剂可以调节循环RNAs (circRNAs) 以对抗与氧化应激相关的疾病. 这篇评论探讨了抗氧化剂,如奎尔素和黄素如何影响circRNA网络的治疗潜力.
科学领域:
- 分子生物学分子生物学
- 在RNA生物学,RNA生物学.
- 转毒生物学 转毒生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 循环RNA (circRNAs) 是稳定的非编码RNA,在基因表达中起着调节作用.
- 不调节的circRNAs与癌症和神经退行等疾病有关,通常涉及氧化应激.
- 自然抗氧化剂提供了一种恢复氧化还原平衡和影响circRNA网络的策略.
研究的目的:
- 审查自然抗氧化剂如何调节circRNA表达和功能在疾病背景下.
- 要突出抗氧化剂-circRNA相互作用背后的分子机制.
- 讨论基于抗氧化剂的circRNA疗法的挑战和未来方向.
主要方法:
- 对自然抗氧化剂和circRNAs的研究进行了全面的文献综述.
- 分析分子机制,包括circRNA-miRNA-mRNA轴和RBP相互作用.
- 检查特定的抗氧化化合物 (例如,奎尔丁,黄素,白醇).
主要成果:
- 各种天然抗氧化剂 (黄类,多类等) 影响circRNA的表达和功能.
- 抗氧化剂通过circRNAs影响与疾病相关的途径,如氧化应激,炎症和细胞增殖.
- 关键化合物通过circRNA介导的作用显示出治疗潜力.
结论:
- 天然抗氧化剂和circRNAs之间的相互作用是 redox 相关疾病的有前途的治疗途径.
- 需要进一步的研究来阐明机制,改善生物可用性,并验证体内发现的结果.
- 将抗氧化剂治疗与RNA向策略相结合,具有显著的未来潜力.
相关概念视频
lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
Regulation of Expression at Multiple Steps
1.0K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.0K
Types of RNA
64.8K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
64.8K
RNA Stability
33.9K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.9K
Regulation of Expression Occurs at Multiple Steps
23.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
23.4K
siRNA - Small Interfering RNAs
17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K

