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远程缺血条件改善了通过内血管血栓切除术治疗缺血性中风的结果:SERIC-EVT试验

Zhen-Ni Guo^1,2, Reziya Abuduxukuer¹, Chao Wang¹

¹Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, China.

European heart journal

|August 12, 2025

概括

远程缺血条件 (RIC) 改善了中风患者接受内血管血栓切除术的治疗结果. 与假装治疗相比,这种神经保护治疗在90天后导致更好的功能恢复.

科学领域:

神经学神经学
心血管医学心血管医学
临床试验临床试验

背景情况:

尽管进行了内血管血栓切除术,急性大血管封闭性中风往往导致不良结果.
需要有效的神经保护策略来改善这些患者的功能恢复.

研究的目的:

评估远程缺血性调节 (RIC) 作为神经保护治疗的有效性和安全性.
评估RIC对急性缺血性中风患者进行内血管血栓切除术的功能结果的影响.

主要方法:

一个参与者盲目的随机对照试验,涉及25家医院的488名患者.
患者被随机分配,接受RIC (200mmHg袖口压力,每天两次,持续7天) 或假RIC (60mmHg).
主要结局:90天后修改了兰金度数 (0-2) 的得分. 安全结果:在7天内发生出血变化.

主要成果:

在RIC组中的61.1%的患者在90天内实现了良好的功能结果 (mRS 0-2),而在假RIC组中为48.9% (未调整的风险比为1.25,P = .009).
血液变化的发生率在各组之间是相似的 (37.7%在RIC和35.2%在假RIC).

结论:

远程缺血性调节 (RIC) 在90天内显著改善了急性缺血性中风患者的功能结果,这些患者接受了内血管血栓切除术治疗.
在这种患者群体中,RIC似乎是一种安全有效的神经保护干预措施.

关键词:

急性缺血性中风急性缺血性中风血管内血栓切除术是指血管内血栓切除术.预测预测预测预测远程缺血性疾病的条件.

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