在慢性疾病的病理生理学中,基于甘油三的脂毒性
Junjun Liu1, Xiude Fan2, Yongfeng Song1
1Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, China; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging (Shandong First Medical University), Ministry of Education, Jinan, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, China; Shandong Institute of Endocrine & Metabolic Diseases, Jinan, 250021, China; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, China.
宫外甘油三酸沉积,或脂毒性,有助于代谢疾病. 最近的发现表明,肝脏和胰腺等器官中的脂肪沉积会导致各种慢性健康状况.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 细胞生物学 细胞生物学
背景情况:
- 脂毒性,脂肪积累的有害影响,在30年前被概念化.
- 在肝脏,胰腺和脏等器官内异胎性甘油三沉积与代谢功能障碍有关.
- 以前被认为是惰性的,这些脂肪沉积物现在被认为具有病原性潜力.
研究的目的:
- 总结一下目前对基于甘油三的脂质毒性的理解.
- 突出异胎脂肪沉积在慢性疾病发展中的作用.
主要方法:
- 对最近关于脂毒性研究的文献综述.
- 临床观察和实验发现的综合.
主要成果:
- 在非脂肪组织 (宫外部位) 中的甘油三积累是代谢疾病的重要因素.
- 宫外脂肪沉积导致诸如胰腺炎,病,骨质疏松症,甲状腺功能低下症和不孕症等疾病.
- 宫外甘油三的致病作用越来越明显,跨越多个器官系统.
结论:
- 基于甘油三的脂毒性是各种慢性疾病的关键机制.
- 了解子宫外脂肪沉积对于开发代谢障碍治疗策略至关重要.
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