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在 thiopental 镇静后儿童的脑死亡诊断过程:一个比较的回顾性队列研究
Victor Sartorius1, Ann-Marie Crowe1, Alina Marilena Lazarescu1
1Department of Anesthesia and Pediatric Surgical Intensive Care, Necker-Enfant malades Hospital, APHP, Paris, France.
概括
蒂奥潘特尔镇静剂延迟了儿童的脑死亡 (BD) 诊断,延长了关键测试的时间. 多种模式评估,包括门水平和多普勒测量,对于精确的BD诊断在静止后至关重要.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 神经学 神经学
- 器官捐献科学 器官捐献科学
背景情况:
- 脑死亡 (BD) 的确定对于儿科器官捐献至关重要.
- 硫,一种镇静剂,可以混BD诊断.
- 片对儿童BD诊断的影响尚不清楚.
研究的目的:
- 为了比较BD诊断的时间表和过程,在接受了片镇静治疗的儿科患者与没有接受片镇静治疗的儿科患者中.
主要方法:
- 从2012年1月到2020年4月的医疗记录的回顾性分析.
- 包括所有接受 BD 评估和诊断的儿童.
- 诊断时间表和方法之间的thiopental和非thiopental组之间的比较.
主要成果:
- 在硫组中,呼吸暂停和确认性BD测试的时间显著更长 (分别为p=0.015和p=0.019).
- 在接受片治疗的儿童中,器官分配延迟.
- 在经的多普勒测试中,脑血流中断的持续迹象在皮治疗组中更为频繁 (89.7%vs68.9%,p=0.049).
结论:
- 提奥本达的先前使用显著延迟了儿科大脑死亡的诊断.
- 建议在经过硫镇静后对BD诊断进行多式评估,包括硫的血水平和跨的多普勒测试.
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