基于高频超声波的儿童骨龄评估模型:一个前性队列研究
Shujun Chen1, Yijun Xiong2, Junjie Liu3
1Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Ultrasound, The People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Ultrasound in medicine & biology
|August 12, 2025
概括
这项研究开发了一种经过验证的超声波模型,用于估计儿科骨年龄 (BA),提供无辐射替代方案. 该模型显示了高精度和与放射性标准的一致性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 医疗成像医学成像
- 骨的发育 骨的发育
背景情况:
- 基于超声波的骨年龄 (BA) 评估未得到充分利用,缺乏验证.
- 目前的方法通常涉及辐射暴露.
- 需要一个简单,准确,无辐射的BA估计工具.
研究的目的:
- 开发和验证一种简单,准确的基于超声波的模型,用于估计儿科骨龄 (BA).
- 利用高频超声波来评估关键骨部位的骨化速率.
- 为BA评估建立一个无辐射的替代方案.
主要方法:
- 一项涉及2001名儿童的前性研究,分为试点,建模和验证组.
- 高频超声波评估了手腕和膝关节的五个部位的骨化率 (ORs).
- 为BA估计而构建的回归模型,根据TW3-C-RUS放射性标准进行验证.
主要成果:
- 在所有五个地点的OR和BA之间观察到强烈的正相关性.
- 基于超声波的BA在验证队列中显示出与放射性BA (ICC = 0.99) 的良好一致性.
- 异常BA的高诊断性能:93.8%的灵敏度 (男孩),100%的灵敏度 (女孩),100%的特异性 (两性).
结论:
- 已经开发了一个经过严格验证的基于超声波的模型,用于儿科BA评估.
- 该模型表现出高灵敏度,特异性和与放射性标准的一致性.
- 这种超声波方法为BA评估提供了一个临床上有用的,无辐射的替代方案.
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