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用向治疗治疗的不可切除的肝细胞癌患者的结果预测模型

Qiang Ruan¹, Xiaohui Wang², Qiang Li³

¹Department of the Second Area of Gastrointestinal Surgery, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.

Scientific reports

|August 12, 2025

概括

一种新的模型,即针对不可切除肝细胞癌预后的向治疗 (TUHP) 模型,准确地预测了接受向治疗的不可切除肝细胞癌患者的结果,改进了现有的预后工具.

科学领域:

肝胆道医学肝胆道医学
在瘤学瘤学.
临床预测建模临床预测建模

背景情况:

不切除的肝细胞癌 (u-HCC) 缺乏针对性治疗结果的既定预后模型.
针对性治疗如索拉芬尼和伦瓦替尼用于u-HCC,但结果预测仍然具有挑战性.

研究的目的:

为接受向治疗的u-HCC患者开发和验证一种新的预测模型.
提高预测整体存活率 (OS) 和无进展存活率 (PFS) 的准确性.

主要方法:

在三个中心对u-HCC患者接受索拉费尼布或伦瓦提尼布 (2011-2023) 治疗的回顾性分析.
数据分为培训 (70%) 和内部验证 (30%) 集;第三个中心用于外部验证.
开发针对性治疗不可切除肝细胞癌预后 (TUHP) 模型,使用显著预测因素:α-fetoprotein水平≥20 ng/mL和大血管入侵 (MVI).

主要成果:

TUHP模型确定了α-fetoprotein水平≥20 ng/mL和MVI作为训练组中的OS和PFS的独立预测因素.
在验证队列中,TUHP模型与OS和PFS有显著的关联.
与现有的预后模型相比,TUHP模型显示出更高的区分能力.

结论:

在接受向治疗的u-HCC患者中,TUHP模型准确地预测了OS和PFS.
这个模型有可能优化u-HCC的治疗策略和患者的治疗结果.
TUHP模型为u-HCC的向治疗提供了更好的预后准确性.

关键词:

大型血管侵入 (MVI)预测模型是一个预测模型.有针对性的治疗.无法切除的肝细胞癌 (u-HCC)

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