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通过使用乙醇辅溶剂的绿色超临界流体技术提高甲基多巴的溶解度

Hadil Faris Alotaibi¹, Suleiman Ibrahim Mohammad^2,3, Asokan Vasudevan⁴

¹Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint, AbdulRahman University, Riyadh, 11671, Saudi Arabia. Hfalotaibi@pnu.edu.sa.

Scientific reports

|August 12, 2025

概括

这项研究探讨了甲基多巴在超临界二氧化碳 (CO2) 中的溶解性,发现乙醇作为辅溶剂显著提高了溶解性. 索尔塔尼-马兹鲁米模型准确地将实验数据关联起来,突出了增强药物配方的潜力.

科学领域:

化学工程是化学工程的重要组成部分.
制药科学制药科学
物理化学物理化学

背景情况:

甲基多巴是一种重要的抗高血压药物.
超临界二氧化碳 (scCO2) 提供了一个可调节和环保的溶剂系统.
了解甲基多巴在scCO2中的溶解度对于开发先进的药物输送和净化方法至关重要.

研究的目的:

为了研究甲基多巴在超临界二氧化碳中的可溶性.
为了评估乙醇作为辅溶剂对甲基多巴溶解度的影响.
用各种热力学方法建模和关联实验溶解度数据.

主要方法:

在308K至338K的温度下,实验性地确定甲基多巴在scCO2中的溶解度.
包括乙醇作为不同度 (1和3mol%) 的辅溶剂.
应用半经验,经验和-罗宾逊模型进行数据分析.

主要成果:

甲基多巴在scCO2中的溶解度从0.078 × 10−4到1.082 × 10−4.4不等.
乙醇显著提高了甲基多巴的溶解性,在12MPa和338K时最大增加15.70倍.
索尔塔尼-马兹鲁米模型与实验溶解度数据的相关性最高.

结论:

超临界二氧化碳与乙醇是一种有效的溶剂系统,可以提高甲基多巴的溶解度.
热力学建模为scCO2中的甲基多巴溶解度提供了可靠的预测.
这些发现支持scCO2在甲基多巴加工和配方中的潜在应用.

关键词:

二元期权二元期权二元期权是什么二氧化碳是二氧化碳中的一种.相对应关系相对应关系可溶性可溶性溶性这是一个特纳里,Ternary.

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