COVID-19大流行对青少年神经生物学功能的影响
Justin P Yuan1, Lauren R Borchers2, Yoonji Lee2
1Dept. of Psychology, Stanford University, Stanford, CA, USA. yuanjp@stanford.edu.
Translational psychiatry
|August 12, 2025
概括
COVID-19 疫情对青少年神经生物学产生了负面影响. 锁定后,青少年表现出较低的皮质醇,较高的炎症,以及降低前额叶皮质活动,这表明与压力相关的显著生物干扰.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 心理学 心理学 心理学
背景情况:
- 随着COVID-19大流行,人们面临广泛的压力,尤其是青少年的心理健康.
- 与流行病相关的压力对青少年的神经生物学影响在很大程度上仍未得到研究.
研究的目的:
- 调查COVID-19大流行和封锁对青少年关键压力敏感生物系统的影响.
- 为了比较与流行病相关的压力因素之前和之后的青少年的神经生物学功能.
主要方法:
- 分析了154名青少年 (13.9-19.4岁) 的长度研究数据.
- 比较了大流行前和大流行后的小组对下丘脑-垂体-上腺 (HPA) 轴活动,免疫反应和神经对情感刺激的反应.
- 在情感处理过程中评估皮质醇的产生,全身炎症标志物和前额叶皮层的激活.
主要成果:
- 在封锁后评估的青少年显示,与大流行前水平相比,他们的皮质醇总产量显著降低.
- 在封锁后的青少年群体中观察到系统性炎症的升高水平.
- 在情感处理过程中,在锁定后的青少年中发现前额叶皮层的神经活化减少.
结论:
- COVID-19大流行经验与青少年多个压力敏感生物系统的重大破坏有关.
- 这些与流行病相关的生物学变化可能对青少年神经生物学产生持久的不良发展后果.
- 研究结果突出了与流行病相关的压力对青少年发育的深刻生物学影响.
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