氧化铁/银氧化铁纳米颗粒:容易合成,表征,抗菌活性,基因毒性和抗癌评价
Sara Abdelghany1, Ashraf Elsayed2, Hoda Kabary3
1Botany Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Scientific reports
|August 12, 2025
概括
生物合成的银氧化铁纳米颗粒 (IONPs) 显示出增强的抗菌和抗癌特性. 这些环保纳米颗粒显示出药品和治疗应用的巨大潜力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 氧化铁纳米粒子 (IONPs) 具有宝贵的抗菌,抗氧化和抗癌特性.
- 生物合成为纳米粒子生产提供了一种可持续且具有成本效益的方法.
- 银可以增强IONPs的治疗效果.
研究的目的:
- 使用微生物提取物生物合成氧化铁纳米粒子 (IONPs).
- 为增强治疗潜力合成含银合的IONP (Ag-IONP).
- 评估生物合成IONP和Ag-IONP的抗菌和细胞毒性活动.
主要方法:
- IONPs是从Pseudomonas aeruginosa细胞外超级生物中合成的.
- 在IONP上减少了酸银,使用酸来制造Ag-IONP.
- 纳米粒子的表征涉及SEM,EDX,XRD和FTIR光谱.
- 对各种细菌菌株进行了抗菌活性测试.
- 用MTT测定对正常视网膜和A549肺癌细胞进行细胞毒性评估.
主要成果:
- 生物合成通过培养上游生物的颜色变化得到证实.
- SEM揭示了统一的,球形的纳米粒子.
- EDX和XRD证实了磁石 (γ-Fe2O3) 和磁石 (Fe3O4) 的存在.
- 与Fe2O3.3相比,Fe3O4和Ag-dopedFe3O4NP显示出更高的抗菌活性.
- Ag-doped Fe3O4 NPs对A549癌细胞的细胞毒性比IONPs更高.
结论:
- 生物合成的Ag-dopedFe3O4纳米颗粒具有显著的抗菌和抗癌特性.
- 这些纳米粒子是安全的,环保的,并且具有成本效益.
- Ag-doped Fe3O4 NPs显示出对制药和治疗应用的有希望的潜力.
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