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Updated: Sep 8, 2025

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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拓酶1活性的表观遗传控制呈现出癌症脆弱性

Tae-Hee Lee1, Colina X Qiao1,2,3, Vladislav Kuzin4

  • 1Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature communications
|August 12, 2025
PubMed
概括

基因组素变体 macroH2A1.1 通过解决拓聚酶 1 分裂复合体 (TOP1ccs) 来防止DNA损伤. 它的替代拼接影响基因组维护和癌症脆弱性.

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