卵细胞中的光滑内质网膜聚合物:孕激素原和GnRH抗体IVF协议的比较
Hsien-Ming Wu1,2, Cindy Hsuan Weng1, Yen-Ju Sung1
1Department of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Journal of ovarian research
|August 12, 2025
概括
孕激素辅助卵巢刺激 (PPOS) 方案在体外受精 (IVF) 和细胞内精子注射 (ICSI) 周期中是安全有效的. PPOS显示卵细胞质量和怀孕结果与激素释放激素 (GnRH) 抗剂协议相似.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 玻璃化增强了解后的胚胎存活率,使先进的试管婴儿/ICSI策略成为可能.
- 孕激素辅助卵巢刺激 (PPOS) 越来越多地用于IVF/ICSI,因为它的方便性和有效性.
- 人们仍然担心PPOS对卵细胞和胚胎质量的影响.
研究的目的:
- 在IVF/ICSI中比较PPOS和GnRH抗剂协议之间的胚胎和怀孕结果.
- 为了评估卵细胞中光滑内等离子体网膜聚合物 (SERa) 的患病率.
- 评估周期特征和怀孕成功率.
主要方法:
- 在2017年7月至2018年12月期间,对545名接受IVF/ICSI治疗的妇女进行了回顾性队列研究.
- 患者的倾向性得分与PPOS和GnRH抗组相匹配 (1:1).
- 所有可生存的胚胎都被冷保存;主要终点是SERA流行率.
主要成果:
- PPOS组在触发日显示了更长的刺激持续时间和更高的雌激素水平.
- 在不同组中,SERA的患病率相似 (13.0%对12.2%,p=0.221).
- PPOS产生了更多的冷胚胎,特别是在低响应者 (p=0.043) 中;怀孕或活产率没有显著差异.
结论:
- PPOS协议的临床益处和安全性与GnRH抗剂协议相美.
- 卵细胞质量和怀孕结果在PPOS和GnRH抗剂协议之间是相似的.
- PPOS是IVF/ICSI的可行选择,其结果与GnRH抗剂协议相比较.
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