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Updated: Sep 11, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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作为潜在的DprE1抑制剂,设计,合成和生物评估作为抗结核剂的Pyrazolopyridinepyrimidone混合物

Moksh Shah1, Iva Patel1, Pratik Khona1

  • 1Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India.

Scientific reports
|August 12, 2025
PubMed
概括

新型的pyrazolo[3,4-b]pyridine-pyrimidone衍生物对Mycobacterium结核病 (Mtb) 具有强大的抗结核活性. 这些化合物是无毒的,并显示出治疗耐药结核病的潜力.

关键词:
这是一种抗结核药物.在 DFT 方面,它是最重要的.分子对接是分子对接.分子动力学分子动力学皮拉佐洛皮里丁 - 皮里米氨酸

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