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Updated: Sep 11, 2025

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肠道微生物群和白内障之间的因果关系:一个双样本双向孟德尔随机化研究.
Han-Dan Xiao1, Ji-Ang Li, Chen-Han Zhou
1Department of Orthopaedics (H.X., J.L., C.Z., Y.Z.), Xiangya Hospital, Central South University, Changsha, Hunan Province, China; Department of Radiology (H.X.), Xiangya Hospital, Central South University, Changsha, Hunan Province, China; and National Clinical Research Center for Geriatric Disorders (H.X., J.L., C.Z., Y.Z.), Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Eye & contact lens
|August 13, 2025
概括
这项研究表明肠道细菌和白内障之间存在联系. 特定的肠道微生物可能会影响白内障的发展,其中一些可能会降低风险,而另一些可能会增加风险.
科学领域:
- 微生物组研究的研究.
- 眼科医生 眼科 眼科
- 遗传流行病学遗传流行病学
背景情况:
- 在全球范围内,白内障是导致失明的主要原因.
- 人们越来越认识到肠道微生物群在全身性疾病中的作用.
- 了解肠眼轴连接对于新的治疗策略至关重要.
研究的目的:
- 调查肠道微生物群组成和白内障风险之间的潜在因果关系.
- 采用双样本门德尔随机化 (MR) 方法来评估因果关系.
主要方法:
- 利用全基因组关联研究 (GWAS) 对肠道微生物群 (18,340名参与者) 和白内障 (8,890例,454,120对照) 的数据.
- 应用逆方差加权 (IVW) 作为主要分析方法.
- 使用加权中位数,MR-Egger回归和MR-PRESSO强度测试的证实结果.
主要成果:
- 确定了五种细菌特征与白内障风险之间的暗示性关联.
- 克里斯塞拉属R.7,Sellimonas和Eubacterium ruminantium与白内障风险有负相关性.
- 埃格特拉菌和臭虫菌与白内障风险呈现积极关联.
- 在相关的细菌特征中没有发现显著的异质性.
结论:
- 这些发现支持肠道微生物群在白内障发展中的潜在因果作用.
- 需要进一步的研究来阐明将肠道微生物群与白内障发生联系起来的具体机制.
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