2型糖尿病女性体力活动,炎症和认知能力之间的相互作用:一项专注于IL-6通路调解者的观察性研究
Zakieh Heidari1, Mahdieh Molanouri Shamsi2,3, Amin Kadkhodaei1
1Department of Physical Education & Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
2型糖尿病女性的体力活动 (PA) 与可溶性互白素-6受体 (sIL-6R) 和可溶性糖蛋白130 (sgp130) 的水平较低有关,可能改善认知功能. 这突出了PA的重点.
科学领域:
- 内分泌学和新陈代谢学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 2型糖尿病 (T2DM) 与认知障碍有关,其中涉及交联素-6 (IL-6) 途径.
- 可溶性IL-6受体 (sIL-6R) 和可溶性糖蛋白130 (sgp130) 在调解身体活动 (PA) 对T2DM女性认知的影响中的作用尚不清楚.
研究的目的:
- 检查PA,sIL-6R和sgp130水平在T2DM妇女之间的关联.
- 为了研究PA,这些细胞因子水平和这一群体的认知表现之间的关系.
主要方法:
- 对44名患有T2DM的女性 (50-75岁) 的横截面研究.
- 评估了PA,sIL-6R,sgp130,IL-6的血清度,认知表现,身体健康和代谢指标.
- 使用相关性分析和调整后的ANCOVA分析相关性.
主要成果:
- 与不活跃女性相比,活跃女性的sIL-6R和sgp130水平明显较低 (p <0.05).
- 较低的sIL-6R和sgp130水平与更好的处理速度和视觉空间功能相关,即使在调整后.
- 血压还与改善的胆固醇,禁食血糖 (FBS) 和心血管健康有关.
结论:
- 患有T2DM的女性常规的PA与sIL-6R和sgp130水平的降低有关.
- 这些降低的水平可能有助于提高处理速度和视觉空间功能等领域的认知性能.
- 抗胰岛素是一种潜在的支持策略,用于控制炎症并减轻T2DM的认知衰退.
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