肠道微生物群通过调节突触可塑性,与双相情感障碍中的认知障碍有关
Anying Tang1,2,3,4, Hangyuan Jiang1,5,6, Jie Li1
1Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
肠道微生物群的改变与双相情感障碍 (BD) 的认知障碍有关. 这项研究发现,肠道细菌的变化会影响小鼠的大脑可塑性和行为,这表明BD认知缺陷的潜在治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 认知障碍是双相情感障碍 (BD) 的一个重大挑战,其潜在机制尚不清楚.
- 新兴研究表明肠道微生物群和认知功能之间存在联系,可能是通过突触可塑性调节.
研究的目的:
- 描述双相情感障碍患者的肠道微生物结构,包括有或没有认知障碍的患者.
- 在小鼠模型中研究肠道微生物群对神经可塑性和认知功能的影响.
主要方法:
- 16S-核糖体RNA基因测序用于分析BD患者和健康对照者的肠道微生物群组成.
- 从BD患者移植便微生物群到无菌小鼠,然后进行行为测试和评估神经元可塑性.
- 在BD-CI小鼠中对健康微生物群进行干预,以评估认知和情绪缺陷的逆转.
主要成果:
- 在BD患者和对照人群中观察到肠道微生物多样性和组成的显著差异.
- 特定的细菌系与BD患者的认知障碍和抑郁症严重程度相关.
- 便微生物群移植在接受者小鼠中诱导了类似抑郁症的行为和记忆障碍,BD-CI微生物群导致更严重的缺陷和减少神经元可塑性.
结论:
- 在具有认知障碍的双相情感障碍患者中,肠道微生物群的组成发生了改变.
- 肠道微生物群通过影响神经元可塑性,在BD相关的认知缺陷中发挥着至关重要的作用.
- 准肠道微生物群可能为双相情感障碍的认知功能障碍提供一种新的治疗策略.
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