利用内微生物群:免疫微环境和免疫治疗的新视野
Jinhe Zhang1, Zinan You1, Xinqiao Li2
1Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, Shenyang, 110001, People's Republic of China.
Journal of translational medicine
|August 13, 2025
概括
内微生物群通过调节瘤微环境,显著影响癌症进展和免疫疗法的疗效. 了解这些微生物为基于微生物群的癌症诊断和个性化治疗提供了新的途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 微生物居住在人体瘤中,影响瘤微环境 (TME).
- 内微生物群越来越多地被认为是固体瘤进展的关键调节者.
研究的目的:
- 审查内微生物群的起源和异质性.
- 阐明它们在免疫调节,瘤转移和癌症免疫治疗中的作用.
- 讨论针对新型微生物群的治疗策略.
主要方法:
- 文献综述综合了关于内微生物群的当前研究.
- 分析微生物对免疫因子 (例如,IFN-γ,TNF-α) 和免疫细胞透的影响.
- 探索治疗方法,包括工程细菌和纳米粒子.
主要成果:
- 内微生物调节TME内的免疫反应和免疫细胞活性.
- 微生物群失调免疫检查点表达,影响免疫治疗结果.
- 在不同类型的癌症中,微生物的组成各不相同.
结论:
- 内微生物群是癌症发展和治疗反应的关键参与者.
- 针对这些微生物为新型癌症诊断和个性化免疫疗法提供了机会.
- 对微生物与宿主相互作用的进一步研究对于推进癌症治疗至关重要.
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