环保和超灵敏的电化学传感器用于药品和等离子体中的塞特拉林检测
Ramy E El-Bahnasawy1, Hany A Batakoushy1,2, Hytham M Ahmed3,4
1Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Shebin Elkom, Menoufia, 32511, Egypt.
BMC chemistry
|August 13, 2025
概括
一个新的甲蓝 (MB) 改性电极增强了塞特拉林 (SRT) 检测. 这种环保的电化学传感器在各种样本中提供高灵敏度和选择性SRT测定.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 塞特拉林 (SRT) 是一种广泛使用的选择性血清素再吸收抑制剂.
- 需要敏感和选择性的电化学方法来确定SRT.
- 甲蓝 (MB) 可以电聚合,以创建功能性电极材料.
研究的目的:
- 开发一种使用电聚合乙烯蓝 (MB) 改造的玻璃碳电极 (GCE),用于增强电化学测定塞特拉林 (SRT).
- 描述修改后的电极并评估其用于SRT检测的性能.
主要方法:
- 乙烯蓝 (MB) 在玻璃碳电极 (GCE) 上的电聚合.
- 使用FTIR,EDX和SEM进行材料表征.
- 电化学分析包括循环电压测量,微分脉冲电压测量 (DPV) 和电化学阻抗光谱 (EIS).
- 在各种矩阵中确定检测极限 (LOD) 和评估选择性和回收.
- 使用AGREE,AGREEprep,MoGAPI,NQS指数和RGB 12算法对方法的环保性和可持续性的评估.
主要成果:
- 在GCE上成功形成聚甲蓝 (PMB) 薄膜,通过材料表征证实了这一点.
- 与裸体GCE相比,PMB/GCE表现出增强的电子转移动力学和改进的电活性表面积.
- 超灵敏的SRT检测具有0.28μM的低检测极限 (LOD).
- 在制药样品和的血中,高灵敏度,选择性和优异的恢复率 (99.08-101.09%) .
- 提出的方法证明了卓越的环保性,成本效益和分析稳定性.
结论:
- 开发的聚甲蓝 (PMB) / GCE 传感器提供了一个高度敏感,选择性和强大的平台,用于电化学测定塞特拉林 (SRT).
- 该方法是环保的,具有成本效益,适合在现实世界样本中分析SRT.
- 这项工作为制药分析提供了可持续和高效的电化学方法.
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