一项孟德尔的随机化研究,研究了饮食因素和静脉血栓塞栓症之间的因果关系
Quan Ling1, Kepeng Liu, Jiao Liu
1The First Department of Anesthesia, Zhongshan City People's Hospital, Zhongshan City, Guangdong Province, China.
Medicine
|August 13, 2025
概括
吃家禽可能会增加静脉血栓塞栓症 (VTE) 的风险. 这项研究没有发现油性鱼或新鲜水果摄入量与VTE之间的因果关系,这表明饮食选择会影响VTE风险.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 饮食因素越来越多地被认为对静脉血栓塞栓症 (VTE) 的潜在影响.
- 了解特定食物摄入量和VTE之间的因果关系对于公共卫生建议至关重要.
研究的目的:
- 调查饮食因素,特别是家禽,油性鱼和新鲜水果摄入量对静脉血栓塞栓症 (VTE) 风险的潜在因果影响.
主要方法:
- 一项孟德尔随机化 (MR) 研究,利用来自英国生物银行和FinnGen.com的全基因组关联研究数据.
- 选择单核酸多态 (SNP) 作为饮食摄入量和VTE的仪器变量.
- 应用五种回归模型 (MR-Egger,反变量加权,加权中位数,加权和简单模型) 来评估因果关系.
- 评估结果的稳定性和异质性,使用科克兰的Q测试,散射图,漏斗图和留下一个漏洞分析.
主要成果:
- 禽类的摄入量被确定为VTE的重要危险因素 (OR=5.265,95% CI:1.337-20.738,P<0.05).
- 油性鱼类摄入量或新鲜水果摄入量与VTE之间没有发现显著的因果关系.
- 分析表明,在选定的SNP中没有显著的异质性或性,这支持了研究结果的稳定性.
结论:
- 禽肉消费可能是发展静脉血栓塞栓症 (VTE) 的危险因素.
- 油性鱼和新鲜水果的饮食摄入量似乎与VTE风险没有显著的因果关系.
- 这些发现强调了在VTE预防策略中考虑特定的饮食成分的重要性.
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