中度急性营养不良儿童的肝功能测试:布基纳法索随机试验的二次分析
Christina L Winther1, Thora W Helt2, Christian Fabiansen3
1Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Journal of pediatric gastroenterology and nutrition
|August 13, 2025
概括
患有中度急性营养不良 (MAM) 的儿童没有明显的肝损伤. 然而,这些儿童的发育迟缓可能表明亚临床肝损伤,需要进一步调查与营养不良相关的肝病.
科学领域:
- 儿童营养学 儿童营养学
- 肝病学 肝病学是一种肝病学.
- 全球健康 全球健康
背景情况:
- 在严重的急性营养不良中记录了肝硬化症.
- 中度急性营养不良 (MAM) 的肝损伤仍未得到充分研究.
- 研究MAM的肝功能对于了解营养不良的影响至关重要.
研究的目的:
- 为了评估MAM儿童的肝功能测试.
- 为了确定与中度急性营养不良相关的潜在亚临床肝损伤.
- 描述一组患有MAM的儿童的肝功能测试结果.
主要方法:
- 在布基纳法索的随机2x2x3因数试验 (Treatfood).
- 患有MAM的6-23个月龄的儿童接受了不同的营养补充剂.
- 肝功能测试和疟疾快速诊断测试在基线和3个月后进行.
主要成果:
- 大多数肝功能测试在基线处处于正常范围内.
- 长度相对年龄Z分数<-3的儿童的总 bilirubin 度较高.
- 干预后观察到肝功能测试的轻微变化.
结论:
- 在患有MAM的儿童中没有检测到明显的肝损伤迹象.
- 发育不良儿童的胆红素升高表明潜在的亚临床肝损伤.
- 需要进一步的研究来了解儿童的营养不良相关的肝病.
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