用于结肠向的装有卡佩奇他的微海绵的配方和评估
Subhabrota Majumdar1, Sanjay Dey2, Beduin Mahanti3
1Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology & AHS, Banitabla, Uluberia, Howrah- 711316, West Bengal, India.
Current drug delivery
|August 13, 2025
概括
针对结肠的capecitabine (CAP) 微海绵是为了提高口服生物利用性而开发的. 优化的配方证明了持续释放和增强的CAP交付,以有效管理结肠癌.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 在瘤学瘤学.
背景情况:
- 皮他 (CAP) 是5-甲的口服化疗前药物,用于转移性乳腺癌和结肠癌.
- CAP抑制了DNA合成,从而减缓了瘤的进展.
研究的目的:
- 为了开发向结肠的卡佩奇他 (CAP) 载微海绵.
- 使用准乳液溶剂扩散技术,使用基纤维素 (HPC) 和乙烯纤维素 (EC) 聚合物.
主要方法:
- 通过准乳液溶剂扩散配制加载CAP的微海绵.
- 使用3^2因数设计进行统计优化.
- 在Albino Wistar老鼠中的体内药理动力学评估.
主要成果:
- F1配方 (1:1 HPC:EC,1000rpm) 显示最佳的药物释放 (69.57%在12h) 和高捕获效率 (73.09%).
- 与水溶液相比,优化的微海绵显著改善了CAP的口服生物可用性 (1.48倍AUC0-∞增加,p<0.05).
结论:
- 开发的CAP装载微海绵显示出持续的结肠输送capecitabine的潜力.
- 这种配方增强了口服生物可用性,为结肠癌治疗提供了有前途的方法.
- 建议对比较评估和稳定性的进一步研究.
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