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在常规成年桃体切除术中,基于组织病理学诊断的隐性恶性病变的发生率
Yasine Mirmozaffari1, W Jared Martin1, Ezer H Benaim2
1University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
The Laryngoscope
|August 13, 2025
概括
由于良性原因,成年桃体切除标本中隐性恶性瘤很少见,但由于人类乳头瘤病毒 (HPV) 相关的口腔状细胞癌 (OPSCC) 发生率增加,警至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的口腔状细胞癌 (OPSCC) 的发病率不断上升,需要重新评估诊断方案.
- 成人桃体切除样本对于检测隐性恶性瘤越来越重要.
研究的目的:
- 确定在成年桃体切除标本中隐性恶性瘤的当代流行率.
- 为了评估与HPV相关的OPSCC上升的背景下,对当前的组织病理学检查方案的影响.
主要方法:
- 对成年桃体切除病例 (2018-2022) 的回顾性图表审查.
- 分析病理学报告,临床指标,人口统计,吸烟史,HPV疫苗接种状态和p16免疫组织化学.
- 在良性和可疑的手术指示之间,恶性瘤发病率的比较.
主要成果:
- 在1328例患有良性征兆的病例中,发现了两种隐性恶性瘤 (0.15%).
- 在有可疑迹象的病例中,恶性癌症的发病率为32.8%,主要是状细胞癌.
- 与HPV相关的OPSCC发生在没有传统风险因素的接种疫苗的年轻女性中;p16阳性率高 (95.5%).
结论:
- 调查结果与现有的发病率一致,但强调需要在组织病理学评估中保持持续警.
- 随着患者风险概况的不断变化和HPV相关癌症的增加,需要适应的诊断方法.
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