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开发VNX-101,一种具有较低免疫性和有效的长期表达CD19 T细胞参与者的腺相关病毒

Mark A Currier1, Allen Reha2, Brian Hutzen1

  • 1Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Molecular therapy. Methods & clinical development
|August 13, 2025
PubMed
概括

使用VNX-101进行重组腺相关病毒 (AAV) 基因疗法,对B细胞恶性瘤有望. 这种疗法有效地消除瘤,在临床前模型中具有强大的安全性.

关键词:
在B细胞白血病/淋巴瘤.CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19腺相关病毒,AAV.生物分销生物分销双特异性T细胞参与者.毒理学 毒理学 毒理学

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...