相关实验视频
Updated: Sep 11, 2025
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.6K
在三阴性乳腺癌中,SHCBP1驱动瘤进展
Huiling Wang1, Huijuan Dai1, Liheng Zhou1
1Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in oncology
|August 13, 2025
概括
在三阴性乳腺癌 (TNBC) 中,SHCBP1 过度表达,促进细胞增殖和迁移. 这项研究确定了SHCBP1作为攻击性TNBC的潜在治疗标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有有限治疗选择的侵袭性亚型.
- 迫切需要新的分子点来对抗TNBC的进展.
- 这项研究调查了TNBC中SHCBP1的致癌功能.
研究的目的:
- 研究SHCBP1在三阴性乳腺癌 (TNBC) 中的作用.
- 确定TNBC中SHCBP1的预后意义和生物功能.
- 探索SHCBP1作为TNBC的潜在治疗点.
主要方法:
- 从TNBC样本中获取并分析了大量RNA-seq和单细胞测序 (scRNA-seq) 数据.
- 通过生物信息学和实验方法 (qPCR,西式涂抹,免疫光) 评估SHCBP1的表达,预后意义和生物功能.
- 评估了SHCBP1对TNBC细胞增殖和迁移在体外的影响.
主要成果:
- 在TNBC组织中,SHCBP1的调节显著上升,并与较差的存活率有关.
- 过度表达SHCBP1增强了TNBC细胞的增殖和迁移.
- 与SHCBP1相关的基因在细胞循环调节和DNA损伤反应途径中得到丰富;较高的SHCBP1表达与树皮细胞相互作用相关.
结论:
- 在TNBC的进展中,SHCBP1起着关键作用.
- SHCBP1是TNBC的一个潜在的治疗点.
- 这些发现为开发基于SHCBP1的TNBC治疗策略提供了基础.
相关概念视频
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
02:33Hedgehog Signaling Pathway
7.5K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.5K
01:20The Retinoblastoma Gene
4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K