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终身高脂肪,高糖饮食导致小鼠后代的性别特异性心脏功能障碍
Yun-Ju Fang1, Filip Konecny2,3, Eunhee Chung1
1Department of Kinesiology, University of Texas at San Antonio, San Antonio, TX, USA.
Academia medicine
|August 13, 2025
概括
在发育过程中,母亲的高脂肪,高糖 (HFHS) 饮食暴露导致后代的长期心脏功能障碍. 这项研究揭示了性别特异性的心脏问题,女性经历了更大的心室硬和合缺陷.
科学领域:
- 心血管科学 心血管科学
- 发育生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 孕产妇肥胖和高脂肪,高糖 (HFHS) 饮食与后代心脏代谢风险增加有关.
- 发育期HFHS暴露对心脏的长期性别特异性影响尚不清楚.
研究的目的:
- 调查持续HFHS饮食暴露对男性和女性后代心脏功能的长期影响.
- 为了确定发育期HFHS暴露后心脏力学和血液动力学的性别特异性变化.
主要方法:
- 在怀孕和哺乳期间和之前,雌性小鼠被食控制 (CON) 或HFHS饮食.
- 后代被维持在各自的母亲的饮食,直到29-32周的年龄.
- 通过压力-体积 (P-V) 循环分析来评估身体组成和心脏功能.
主要成果:
- HFHS后代表现出体重和脂肪量增加,男性表现出更大的脂肪.
- 两性都表现出缩功能障碍,其特点是体积增加,射出分数和弹性减少.
- 观察到性别特异性透气功能障碍:男性的放松速度较慢,而女性则表现出心室硬度增加和更明显的心室动脉脱.
结论:
- 发育性HFHS暴露会以性别特定的方式诱导显著的长期心脏功能障碍.
- 女人更容易患腹功能障碍,特别是心肌硬和心室动脉合障碍.
- 这些发现强调需要针对性别的干预措施,以解决与早期饮食暴露相关的心血管风险.
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