晚期非小细胞肺癌的免疫疗法与放射疗法相结合:当前状况和挑战 (综述)
Qiong Li1, Ya-Qin Cai1, Li-Hua Shao1
1Department of Radiation Oncology, Gansu Provincial Cancer Hospital, Gansu Provincial Academy of Medical Science, Lanzhou, Gansu 730050, P.R. China.
Oncology letters
|August 13, 2025
概括
将免疫疗法与放射疗法结合起来,可以为高级非小细胞肺癌 (NSCLC) 提供协同作用的抗瘤效应. 本综述探讨了这种组合的合理性,有效性和安全性,强调了改善患者结果的潜在好处和挑战.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了高级非小细胞肺癌 (NSCLC) 治疗.
- 在一些患者中,有限的应答率和长期益处需要新的治疗策略.
- 结合免疫疗法和放射疗法 (RT) 正在研究,以提高治疗疗效.
研究的目的:
- 审查在高级NSCLC中将RT与免疫疗法结合使用的理由,疗效和安全性.
- 检查免疫激活和毒性减轻的最佳RT策略 (时间,剂量,分量).
- 讨论RT在克服免疫疗法耐药性的潜力.
主要方法:
- 在高级NSCLC中结合RT和免疫治疗的研究的综合文献综述.
- 分析RT增强免疫反应的机制.
- 评估关于疗效,安全性和患者选择的临床数据.
主要成果:
- RT可以通过免疫细胞死亡和瘤微环境调节来增强免疫反应.
- 组合疗法显示出协同作用的抗瘤作用和改善的全身控制.
- 有证据表明,RT可以克服对免疫疗法的原发性和获得性耐药性.
结论:
- 将免疫疗法与RT结合起来,有望改善晚期NSCLC的治疗结果.
- 需要进一步的研究来解决患者选择,生物标志物,毒性和最佳治疗时间方面的挑战.
- 整合RT和免疫疗法需要仔细考虑当前的证据和临床实践.
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