标记NSAID过敏和阿片类药物处方的风险;一个观察性研究
Laila Carolina Abu Esba1,2,3, Reham Alhoraibi4, Salem Abu Al-Burak5
1Pharmaceutical Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Frontiers in allergy
|August 13, 2025
概括
无抗药过敏与由于避免而导致的较高阿片类药物处方率有关. 许多患者可以安全地使用替代的NSAID,强调需要更好的分类和处方指导.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 是常见的止痛药,但经常引起药物过敏反应.
- 对NSAID反应的错误分类导致不必要的避开,可能会增加阿片类药物使用.
- 了解NSAID过敏症对于适当的疼痛管理策略至关重要.
研究的目的:
- 为了确定NSAID过敏的患病率和特征.
- 为了研究NSAID交叉反应模式.
- 评估NSAID过敏和阿片类药物处方之间的关联,探索COX-2抑制剂作为替代品.
主要方法:
- 记录NSAID过敏症患者的回顾性队列研究 (2016-2023年).
- 数据收集包括人口统计,反应类型,交叉反应性和阿片类药物处方.
- 后勤回归分析了NSAID过敏和阿片类药物处方之间的联系,与青素过敏进行比较.
主要成果:
- 在319名患者中,30%患有真正的NSAID过敏,12.5%伪过敏,57%未分类.
- 交叉反应发生在13%,但52%的人耐受其他NSAID.
- NSAID过敏性增加了阿片类药物处方的概率62% (aOR 1.62),与未充分利用的塞莱科克西布.
结论:
- 无抗药过敏与阿片类药物处方增加有关,这是由于全班避免.
- 许多患者可以耐受替代性NSAIDs,挑战广泛避免的需要.
- 改进的诊断工具和决策支持对于准确的NSAID过敏性分类和管理至关重要.
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