在被诊断为固体癌症的患者中,B12/CRP比率 (BCR) 的预后值
Merve Keskinkilic1,2, Elif Cetin Basaran3, Tugba Yavuzsen1
1Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
Clinical Medicine Insights. Oncology
|August 13, 2025
概括
血清维生素B12水平/CRP比 (BCR) 可以预测固体癌症患者的预后. 较低的BCR水平与转移性和非转移性组的死亡风险显著增加相关.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 固体癌症对全球健康构成重大负担.
- 预后标记对于定制癌症治疗策略至关重要.
- 血清维生素B12水平/CRP比 (BCR) 之前没有作为癌症预后指标进行过研究.
研究的目的:
- 为了评估血清维生素B12水平/CRP比率 (BCR) 的预后意义,在患有固体癌症的患者中.
- 确定BCR是否可以作为可访问的炎症标志物来预测癌症患者的结果.
主要方法:
- 对344名被诊断患有固体癌症的成年患者的数据进行了回顾性分析.
- 使用接收器运行特征 (ROC) 分析确定BCR截止值.
- 统计分析以评估BCR水平,疾病状态 (转移与非转移) 和死亡率之间的关系.
主要成果:
- 在BCR<3.5 (转移性) 和<3.8 (非转移性) 的患者中,死亡率显著更高.
- 通过BCR识别的高风险患者的死亡率明显更高,平均整体存活时间 (mOS) 更短.
- BCR是一个易于获得和具有成本效益的标记.
结论:
- 血清维生素B12水平/CRP比 (BCR) 是固体癌症患者的新且有价值的预后标志物.
- BCR提供了一种简单,廉价和易于使用的方法来评估炎症和预测结果.
- 对BCR的进一步研究可能会导致改善患者管理和风险分层.
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