自功能在肺巨细胞和树突细胞中,调节过敏原依赖的炎症反应
Neha Dubey1, Reilly Woodson1, Skyler V Hendrix1
1Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
bioRxiv : the preprint server for biology
|August 13, 2025
概括
在严重的喘模型中,自蛋白ATG5抑制TH17反应和中性粒细胞肺积累. 这一发现揭示了难以治疗的过敏呼吸道炎症的新治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 严重的喘包括TH17/TH1反应和中性粒细胞炎症,导致皮质类固醇不敏感.
- 在ATG5基因中的单核酸多态性与严重喘风险的增加有关.
- 在过敏炎症中ATG5的特定功能在很大程度上是未知的.
研究的目的:
- 调查ATG5和自在过敏气道炎症中的作用.
- 确定ATG5如何影响T细胞反应和肺部免疫细胞积累.
主要方法:
- 利用家用灰尘虫 (HDM) 挑战和卵泡胺诱导的过敏气道炎症的小鼠模型.
- 研究了ATG5在肺巨细胞和树突细胞 (DC) 中的功能.
- 评估了TH17,TH1和TH2的反应,以及中性粒细胞和氨粒细胞的积累.
主要成果:
- 自依赖的ATG5抑制了TH17反应和中性粒细胞的积累在HDM挑战的小鼠.
- 自促进了TH2-主导卵蛋白模型中的乙氨基酸积累.
- 巨细胞中的ATG5抑制了HDM诱导的中性粒细胞招募细胞因子和化学因子分泌,独立于T细胞.
结论:
- 自在过敏气道炎症中起着不同的作用,抑制TH17反应和中性粒细胞的涌入,同时促进TH2反应.
- 在严重的喘中,ATG5介导的自对于限制中性粒细胞积累至关重要.
- 这些发现强调了自作为严重的中性粒细胞驱动性喘的潜在治疗标.
相关概念视频
Immune Surveillance by NK Cells and Phagocytes
2.8K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
2.8K
Autophagy
4.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.6K
Phagocytosis of Apoptotic Cells
4.0K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
4.0K
Delivery Pathways to the Lysosome
7.2K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
7.2K
Cells of the Innate Immune Response
3.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
3.2K
Antigen Presenting Cells
2.1K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.1K


