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在神经元衰老过程中,RNA会引发慢性压力

Kevin Rhine1,2,3, Elle Epstein1,2,3, Natasha M Carlson4,5

  • 1Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

bioRxiv : the preprint server for biology
|August 13, 2025
PubMed
概括

线粒体衍生双链RNA (dsRNA) 激活老年神经元的综合应激反应 (ISR),从而导致神经退行. 抑制PKR激酶可以恢复细胞功能和翻译.

关键词:
老化的老化 衰老的老化这是一种双链RNA.综合应激反应综合应激反应线粒体中的线粒体.神经退行症的神经退行症压力颗粒是压力颗粒.

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