噪音驱动的形态发生独立于转录性调节程序
Jack Toppen1,2, Saeed Tavazoie1,3,4
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
bioRxiv : the preprint server for biology
|August 13, 2025
概括
发展是由静态基因表达驱动的,而不仅仅是固定的程序. 这个过程,即随机调节驱动的形态发生 (STM),使用试错来优化细胞命运和组织模式.
科学领域:
- 发育生物学是发展生物学.
- 系统生物学 系统生物学
- 遗传学 是一个遗传学.
背景情况:
- 传统的发育模型强调确定性的转录程序.
- 基因表达中的随机性通常被视为阻碍发育的噪音.
- 现有的范式忽视了随机性在生物自我组织中的潜在作用.
研究的目的:
- 引入随机调节驱动的形态发生 (STM) 作为理解发展的新框架.
- 提出基因表达噪声是形态发生的一个主要驱动因素,而不是障碍.
- 提出一个新的模型,其中的发展是以强化学习原则为指导的.
主要方法:
- 概念框架开发 (STM).
- 类似于用于优化基因表达的强化学习.
- 专注于信号中心,整合感官信息以加强转录变化.
主要成果:
- STM假定随机基因表达变化是由信号中心前调节的.
- 细胞命运通过一个试错过程被引导到最佳的多细胞配置.
- 通过这种机制,发育过程可以对分子和环境的波动保持稳定.
结论:
- 基因表达中的随机性是使适应性发展成为可能的关键机制.
- STM提供了一个自我组织的,强大的替代方案,以确定发展方案.
- 这个框架将噪声重新解释为形态发生和细胞命运决定中的建设性力量.
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