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模拟隐藏的认知状态揭示了芬太尼对决策的急性和慢性影响
Zhenlong Zhang1, Patricia H Janak2,3,4, Eric Garr2
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
bioRxiv : the preprint server for biology
|August 13, 2025
概括
芬太尼改变了决策的动态. 急性使用将老鼠从目标导向转变为习惯性行为,而慢性使用会损害目标导向控制,揭示药物诱导的认知变化.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 行为和认知过程是动态的,在各种时间范围内发生变化.
- 药物,如芬太尼,对这些动态决策模式的影响尚未完全理解.
研究的目的:
- 研究芬太尼如何影响学习和决策的动态认知机制.
- 描述急性和慢性芬太尼暴露对行为策略的影响.
主要方法:
- 应用了强化学习模型,从两步任务中对老鼠选择数据进行强化学习,使用芬太尼和砂糖奖励.
- 利用潜态动态模型,其中代理贡献随时间变化.
- 采用缩小维度的方法,在不同主体之间调整潜在状态,并确定行为策略.
主要成果:
- 确定了三种不同的潜在状态:目标导向,习惯性和新奇性驱动.
- 急性芬太尼增加了从目标导向到习惯驱动状态的过渡.
- 慢性芬太尼减少了习惯主导状态内的目标导向控制,不论性别.
结论:
- 芬太尼能动态地重塑决策过程和认知架构.
- 潜态建模与维度减小相结合,有效地揭示了药物诱导的认知变化.
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