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Updated: Jul 31, 2026

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通过抑制微质cGAS-STING轴,通过RORα激活的线粒细胞衰减减低毒性缺血性脑病变

Lei Song1, Haiyan Shen1, Fei Hong1

  • 1Department of Pediatrics, Nantong First People's Hospital (Second Affiliated Hospital of Nantong University), Nantong, Jiangsu, China.

Frontiers in immunology
|August 13, 2025
PubMed
概括

与视网膜酸受体相关的孤儿受体α (RORα) 通过增强线粒细胞衰变来解决缺氧缺血性脑病 (HIE) 中的神经炎症. 这抑制了有害的信号通路,为HIE提供了新的治疗策略.

关键词:
在NLRP3炎症酶组中,RORα 是一个RORα.在cGAS-STING路径中.缺氧-缺血性脑病变 - - 脑病变.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.神经炎症是一种神经炎症.这就是 scRNA-seqq.

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