抗精神病药物在双极性障碍中的使用:临床和基因组相关-梅奥诊所双极性障碍生物库研究
Balwinder Singh1, Ada Man-Choi Ho1, Brandon J Coombes1
1Mayo Clinic.
Research square
|August 13, 2025
概括
第二代抗精神病药物 (SGA) 用于双相情感障碍 (BD),但反应不同. 一项全基因组研究发现,GAS7变异可能预测BD中的SGA反应,尽管需要进一步研究.
科学领域:
- 精神病学是一个精神病学.
- 药物基因组学 药物基因组学
- 遗传学 是一个遗传学.
背景情况:
- 对情绪稳定剂的治疗反应,包括第二代抗精神病药物 (SGA),是可变的.
- 调查影响SGA反应的临床和遗传因素对于个性化治疗至关重要.
研究的目的:
- 为了确定BD中SGA治疗反应的临床相关性.
- 进行第一个全基因组关联研究 (GWAS) 的SGA药基因组治疗反应在BD.
- 探索多基因分数 (PGS) 以预测BD中的SGA反应.
主要方法:
- 使用Alda尺度量化治疗反应,用GWAS对Alda-A得分进行.
- 对包括性别,基因型分组和基因组主要组成部分在内的共变量进行控制.
- 分析了2,159名患有BD的成年人的数据,包括那些接受了SGA治疗的人.
主要成果:
- 在SGA响应 (Alda-A得分) 和GAS7变体 (顶部变体:rs202127418,p=4.96E-08) 之间发现了全基因组显著的关联.
- SGA使用者表现出更高的躁狂精神病和饮食障碍 (厌食症, Bulimia Nervosa,暴饮暴食障碍) 的比率.
- 对于精神分裂症,BD或严重抑郁症,SGA反应和PGS之间没有发现显著的关联.
结论:
- SGAs通常用于BD,并与躁狂精神病和饮食障碍有关.
- GAS7变种显示出作为BD中SGA反应预测者的潜力.
- 需要更大,更多样化的队列来验证这些发现.
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