相关实验视频

Updated: Sep 11, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

8.8K

一个分子动力学协议,用于快速预测EGFR过活化,并将其应用于罕见突变S768I,S768N,D761N

Julian Behn1,2, R N V Krishna Deepak1,3, Jiancheng Hu4,5

  • 1Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), Singapore 138671, Singapore.

Computational and structural biotechnology journal
|August 13, 2025
PubMed
概括

一个新的分子动力学协议迅速揭示了表皮生长因子受体 (EGFR) 突变如何导致疾病. 这种方法有效地表征了新型EGFR变异,有助于癌症研究.

关键词:
一个不对称的二元体.癌症突变 癌症突变皮肤表皮生长因子受体.基因酶激酶的使用方法分子动力学模拟模型一个对称的二元体.

更多相关视频

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay10:57

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay

Published on: August 14, 2018

10.8K
A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds13:34

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Published on: April 6, 2016

10.3K

相关概念视频

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.7K