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检测由于宿主病毒相互作用反应导致的早期损伤在未经治疗的CHB-a试点研究中

Puneet Gandhi¹, Kavita Peter¹, Subodh Varshney^2,3

¹Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India.

Frontiers in cellular and infection microbiology

|August 13, 2025

概括

慢性乙型肝炎 (CHB) 患者表现出高损伤生物标志物,包括血清囊素-C和尿液IL-18BP. 一个新的生物标志物小组在CHB患者中早期检测出亚临床损伤.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
肝病学肝病学是一种肝病学.
生物标志物发现发现

背景情况:

慢性乙型肝炎 (CHB) 与由于病毒与宿主相互作用和炎症导致的功能障碍有关.
在CHB患者中早期发现亚临床损伤对于管理结局至关重要.

研究的目的:

评估和验证蛋白质生物标志物用于早期检测CHB患者的损伤.
单独和组合评估亚临床功能障碍的生物标志物.

主要方法:

一项前性横截面研究,涉及69名CHB患者和69名健康对照.
测量了血清肌素,尿素,肝酶,血清囊素-C (sCys-C),血清中性粒细胞凝酶相关性脂卡林 (sNGAL),血清Fetuin-A (sFet-A),尿路中白素-18结合蛋白 (uIL-18BP) 和尿路损伤分子-1 (uKIM-1).

主要成果:

与对照组相比,CHB患者的sCys-C,sNGAL和uIL-18BP的显著升高,以及sFet-A的下调.
接收器操作特征分析显示,sCys-C (AUC 0.935) 和sNGAL (AUC 0.811) 的诊断准确度很高.
综合生物标志物小组的AUC为0.984,具有97.1%的灵敏度和91.3%的特异性来检测损伤.

结论:

一种新型的非侵入性诊断屏幕有效地检测炎症和早期损伤在CHB患者血清肌素上升之前.
这种生物标志物小组可以帮助预测CHB患者的结局.

关键词:

生物标志物生物标志物慢性乙型肝炎慢性乙型肝炎乙型肝炎病毒的感染.这是一种炎症炎症炎症炎症.造成脏损伤的人.

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