在SIMI中,SOFA和APSIII得分对28天死亡风险的预测价值:基于MIMIC-IV数据库的队列研究
Chang Liu1, Hao Wang1, Chenyang Liu1
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in cellular and infection microbiology
|August 13, 2025
概括
序列器官衰竭评估 (SOFA) 和急性生理学得分III (APSIII) 有效地预测了败血症引起的心肌损伤 (SIMI) 的死亡率. 这些分数有助于识别高风险患者,以便及时进行临床干预.
科学领域:
- 临界护理医学 临界护理医学
- 心脏病学 心脏病学
- 预测生物标志物 预测生物标志物
背景情况:
- 败血症诱导的心肌损伤 (SIMI) 是败血症的一个关键并发症.
- 准确的预后评分系统对于管理SIMI患者至关重要.
研究的目的:
- 系统地识别和评估用于预测SIMI患者预后的评分系统.
- 评估各种评分系统在预测28天死亡率方面的表现.
主要方法:
- 数据是从MIMIC-IV数据库中提取的.
- 后勤和考克斯回归分析确定了28天死亡率的风险因素.
- 使用ROC曲线,Kaplan-Meier生存率和决策曲线分析 (DCA) 评估预后性能.
主要成果:
- 序列器官衰竭评估 (SOFA) 和急性生理学评分III (APSIII) 被确定为SIMI患者28天死亡的独立风险因素.
- 与其他评分系统相比,SOFA (AUC=0.685) 和APSIII (AUC=0.683) 的预测性能优于其他评分系统.
- 德卡证实,SOFA和APSIII为风险分层提供了更好的净收益.
结论:
- SOFA和APSIII分数是识别SIMI高风险患者的有效工具.
- 这些经过验证的评分系统为SIMI管理中的早期临床干预提供了基于证据的支持.
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