童年逆境预测,在急性压力后,条状功能连接梯度的变化
Xiang-Shen Liu1, Koen V Haak1,2, Karolina Figa1
1Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
儿童时期的逆境,特别是情绪上的忽视,改变了精神病患者的大脑连接. 压力会影响条形状网络组织,特别是在具有高并发症的人群中,为精神疾病提供潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 童年逆境 (CA) 是精神病脆弱的主要风险因素,导致情绪,动机和压力调节的不适应变化.
- 以前的研究表明,一个以条状体为中心的网络参与了与CA相关的精神病理结果,特别是在急性压力下.
研究的目的:
- 在精神疾病中调查童年逆境,急性压力和条纹功能之间的相互作用.
- 探索使用连接梯度的条状连接的功能地形组织.
- 通过检查激励系统中压力诱导的变化来确定心理病理学的潜在生物标志物.
主要方法:
- 在休息状态的fMRI扫描上利用连结体梯度,来自150名精神病患者和26名对照患者,在压力诱导之前和之后.
- 使用斯皮尔曼相关性,分析了与不同类型和频率的CA相关的条状连接梯度.
- 采用线性混合模型和适度模型来评估症状严重程度和并发症的影响.
主要成果:
- 情绪疏忽,一种CA,负面预测后压力梯度形状和改变前后条纹梯度方向.
- 这些相关性在伴随性疾病增加的个体中更为明显.
- 压力引起的条状网络变化被确定为潜在的生物标志物.
结论:
- 童年时期的逆境显著影响了条纹网络的功能组织,特别是在压力下.
- 伴随性疾病在缓解CA,压力和条纹连接性之间的关系方面发挥着至关重要的作用.
- 这些发现为特征状网络变化的新视角提供了新视角,以应对不良体验,并可能导致新的精神病理学生物标志物.
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