对4万个人的全大脑功能连接体分析揭示了大脑网络,这些网络在老年人中表现出衰老效应
Yezhi Pan1,2, Chuan Bi1,3, Peter Kochunov4
1Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
衰老显著改变大脑的连接,特别是在运动网络. 这项研究揭示了感官运动和基底状腺网络内的静止状态功能连接 (rsFC) 与年龄相关的下降,白质完整性起到了调解作用.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 脑部成像 脑部成像
背景情况:
- 衰老过程与大脑结构和功能的显著变化有关.
- 了解大脑功能连接组的变化对于理解与年龄相关的认知和运动衰退至关重要.
研究的目的:
- 系统地评估功能连接组中与衰老相关的变化.
- 用全脑网络分析来识别受衰老影响的特定大脑网络.
主要方法:
- 分析了39675名参与英国生物银行项目的休息状态功能磁共振成像 (fMRI) 数据.
- 利用自适应型密集网络发现工具来识别与年龄相关的网络.
- 在499名参与者中复制了这些发现,这些参与者来自"衰老中的生命周期人类连接组项目".
主要成果:
- 确定了两个与运动相关的子网络,显示了随着年龄的增长而降低的静止状态功能连接 (rsFC) (p < 0.001).
- 第一个网络涉及感觉运动和注意力区域;第二个网络包括基底腺 (尾状腺,门,白球).
- 白质完整性 (微分异型性) 在两个网络 (19.6%和11.5%) 中介于与年龄相关的rsfc下降. 白物质超强度体积介导了第一个子网络中32.1%的效果.
结论:
- 衰老与特定的运动相关大脑网络内的rsFC显著下降有关.
- 白质完整性和白质超强度是调解与年龄相关的功能连接组变化的关键因素.
- 这些发现突显了衰老对运动控制网络的影响以及白质健康的作用.
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