默认模式,前对对和突出网络的发育轨迹从第三个三个月到新生儿时期
Dustin Scheinost1,2,3,4, Joseph Chang3, Emma Brennan-Wydra4
1Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
胎儿和新生儿的大脑网络连接在第三个三个月内显著发展. 母亲的压力会影响突出网络,为神经发育障碍提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 功能神经成像 功能神经成像
背景情况:
- 默认模式 (DMN),前端对称 (FPN) 和突出 (SN) 网络对于行为至关重要,易受干扰.
- 了解这些网络在关键周产期的发展轨迹是必不可少的.
研究的目的:
- 调查DMN,FPN和SN从第三季度到围产期过渡期间的DMN,FPN和SN内部和互联网连接的发育变化.
- 探索母亲心理健康对这些发育中的大脑网络的影响.
主要方法:
- 休息状态功能性MRI被用于在多个时间点 (月经后30-32,34-36和40-44周) 评估84个胎儿和新生儿的连接性.
- 分析了DMN,FPN和SN的内部和网络连接措施.
- 第二次分析检查了母亲压力水平的影响.
主要成果:
- 三个网络 (DMN,FPN,SN) 的内部网络连接在月经后36至44周之间显著增加,在40周后变得积极.
- 在SN和DMN以及SN和FPN之间的连接性显著下降,从36-44周变为负.
- DMN-FPN连接性从30周显著增加到44周,在36周变得积极.
- 较高的母亲压力与在这个发育时期对SN的负面影响有关.
结论:
- 这项研究为怀孕晚期和婴儿早期的大脑网络发展建立了规范框架.
- 研究结果强调了这些网络的关键发展窗口,以及它们对环境因素 (如母亲的压力) 的敏感性.
- 结果为识别有神经行为障碍风险的胎儿和新生儿提供了基础.
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