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全头高密度扩散光学断层扫描绘制婴儿对社会和非社会刺激的视听反应

Liam H Collins-Jones^1,2,3, Louisa K Gossé⁴, Borja Blanco⁵

¹DOT-HUB, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.

Imaging neuroscience (Cambridge, Mass.)

|August 13, 2025

概括

我们为婴儿开发了全头高密度扩散光学断层扫描 (HD-DOT),使其能够全面地绘制大脑活动. 这种新方法在社会处理过程中揭示了比以前可能更广泛的皮质激活模式.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
发展心理学发展心理学

背景情况:

婴儿期是大脑快速发育的关键时期.
高密度扩散光学断层扫描 (HD-DOT) 测量皮质血红蛋白度变化,表明大脑活动.
现有的HD-DOT技术的头皮覆盖范围有限,限制了婴儿大脑的全面成像.

研究的目的:

为婴儿开发和演示全头HD-DOT头盔.
在整个光学可访问的婴儿头皮表面绘制皮质活动的地图.
为了评估5-7个月大的婴儿在社会处理任务期间的功能性大脑激活.

主要方法:

开发了一个基于LUMO设计的全头婴儿HD-DOT系统.
在以屏幕为基础的社会处理任务中,从16名婴儿 (5-7个月大) 收集了HD-DOT数据.
分析了整个头皮的皮层血红蛋白度变化.

主要成果:

在婴儿光学神经成像中实现了前所未有的全头皮覆盖.
在时间区域中确认了激活,与之前的研究相一致.
鉴定了脑后皮层,头皮层和额皮层的新型激活模式,以及在社会处理过程中感觉运动区域的反转反应.

结论:

整体头部HD-DOT提供了婴儿大脑活动的全面映射.
这项技术扩大了婴儿神经成像的范围,揭示了更广泛的功能网络.
未来的应用包括绘制大脑相互作用的地图,以了解典型和非典型的神经发育轨迹.

关键词:

功能近红外光谱学近红外光谱学高密度的扩散光学断层扫描.婴儿的认知发展婴儿的认知发展婴儿神经影像学婴儿神经影像学光学神经影像成像是一种神经影像.

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