休息时的脊髓功能连接:从可行性到可靠性
Ilaria Ricchi1,2, Nawal Kinany1,2, Dimitri Van De Ville1,2
1Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
研究人员证实了在人类腰部神经脊髓中组织的自发血氧水平依赖 (BOLD) 信号. 物理噪声建模有效地提高了信号质量,并揭示了强大的功能连接模式.
科学领域:
- 神经成像是一种神经成像.
- 脊髓生理学 脊髓生理学
- 功能磁共振成像 (fMRI) 是一种功能性磁共振成像技术.
背景情况:
- 自发血氧水平依赖 (BOLD) 信号波动在脊髓中越来越多地被研究,扩展到大脑之外.
- 研究主要集中在椎脊髓上,尽管在下肢功能中的重要性很重要,但 lumbosacral 段仍未得到充分探索.
研究的目的:
- 为了确认人类腰部神经脊髓中组织的自发BOLD信号.
- 评估各种无声化策略对脊柱fMRI信号质量和功能连接 (FC) 的影响.
主要方法:
- 利用fMRI检测到 lumbosacral 脊髓中自发的 BOLD 信号波动.
- 应用并比较多种无声化策略,包括生理噪声建模 (PNM).
- 评估信号质量和功能连接 (FC) 模式,包括分半可靠性.
主要成果:
- 证实了腰部神经脊髓中腹部和背部角之间有组织的双边功能连接 (FC).
- 观察到不同的脱方法中一致的FC模式,显示出相当的时间稳定性.
- 基于生理噪声建模 (PNM) 的消噪管道在保持连接强度的同时在信号清洁方面被证明是有效的.
结论:
- 在人类腰部神经脊髓中展示了强大的内在功能连接 (FC) 模式.
- 突出了基于PNM的denoising对于可靠的脊柱fMRI分析的有效性.
- 为未来研究尾部脊髓活动及其在运动和感觉处理中的作用提供了基础.
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