在快速的全大脑动态中,LSD平整了指导信息流的层次结构
Kenneth Shinozuka1,2,3, Prejaas K B Tewarie4,5,6, Andrea Luppi1,2,7,8
1Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, United Kingdom.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
Lysergic acid diethylamide (LSD) 通过平衡神经信号发送器和接收器来削弱大脑层次结构. 这一发现支持RElaxed Beliefs Under Psychedelics (REBUS) 理论,并改善了机器学习对迷幻状态的分类.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
背景情况:
- 迷幻药物,如lysergic acid diethylamide (LSD),是血清激素药物,可以深刻改变意识.
- 这些影响背后的神经机制尚未完全理解.
- 在psychedelics (REBUS) 下放松的信念理论提出,迷幻药会使大脑信息处理层次结构平坦化.
研究的目的:
- 研究LSD对人类大脑中指导功能连接层次结构的影响.
- 通过检查发送和接收神经信号平衡的变化来测试REBUS理论.
- 通过机器学习来评估层次结构指标在区分迷幻状态方面的实用性.
主要方法:
- 磁脑电图 (MEG) 用于测量16名健康参与者的指导功能连接.
- 参与者在四个条件下 (眼睛开/闭,有/没有刺激) 接受了静脉注射剂量的LSD (75微克).
- 通过发送和接收大脑信号之间的不平衡来评估等级;使用机器学习分类器.
主要成果:
- LSD显著减少了整个大脑的指导功能连接的不对称性.
- 在等级指标上训练的机器学习模型在区分LSD与安慰剂方面显示出较高的准确性,与传统的连接性测量相比.
- 在LSD下观察到神经信号发送器和接收器之间的更平衡的流动.
结论:
- 液会削弱大脑中的指导功能连接层次结构.
- 这些发现提供了证据,支持REBUS理论的预测,即在迷幻药下,神经层次被平坦化.
- 来自定向连接的等级指标提供了一个有希望的方法来识别迷幻诱导的状态.
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