听觉幻象模型作为代理来调查幻觉知觉的自下而上的和自上而下的神经网络
Feifan Chen1, Anusha Yasoda-Mohan2, Colum Ó Sé1
1Lab for Clinical and Integrative Neuroscience, Trinity College Institute for Neuroscience, School of Psychology, Trinity College Dublin, Dublin, Ireland.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
这项研究使用两种幻觉调查了听觉幻觉感知,揭示了不同的大脑活动模式. 这些发现提供了对声机制和潜在的神经调节标的洞察.
科学领域:
- 神经科学是一个神经科学.
- 听觉感知是一种听觉感知.
- 幻影的感觉 幻影的感觉
背景情况:
- 听觉幻觉,就像耳一样,涉及到在没有外部刺激的情况下体验声音.
- 了解幻听感知的神经基础对于开发有效的治疗方法至关重要.
- 自下而上的和自上而下的机制有助于幻听觉感知,但它们的独特神经相关性需要进一步研究.
研究的目的:
- 为了研究底层向上和自上而下的听觉幻觉感知背后的神经机制.
- 要区分与两个听觉幻觉相关的大脑活动:Zwicker音调 (ZT) 和有条件幻觉 (CH).
- 为了确定慢性幻听感知治疗干预的潜在神经点.
主要方法:
- 使用健康参与者的主体内设计.
- 采用了电生理学措施来捕捉不同的时间频率模式.
- 检查了两个听觉幻觉:ZT (感官缺陷驱动) 和CH (多感官期望驱动).
主要成果:
- ZT感知显示中部大脑区域的Theta活动增加.
- CH感知表明,在平顶部区域的theta功率下降.
- ZT涉及默认模式网络区域 (mPFC,lOFC,vPCC) 和预测处理;CH涉及副海马体,内腔皮层和下回.
结论:
- 截然不同的神经机制是底部向上 (ZT) 和上下 (CH) 听觉幻觉感知的基础.
- 这些发现提高了对耳神经机制的理解.
- 确定了神经调节干预措施的潜在神经点,以解决幻觉感知的感觉和认知方面.
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