触发停止过程的可靠性与前额叶-亚thalamic超直接通路的招募有关
Alexandra Sebastian1,2, Birte U Forstmann3, Dora Matzke4
1Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
在停止信号任务中停止触发器的失败与黑色物质和下丘脑核中的大脑活动有关. 这表明停止的可靠性,而不仅仅是速度,取决于这些神经通路.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 停止信号反应时间 (SSRT) 是一种传统的抑制控制度量.
- 它作为抑制标记的实用性受到争论,越来越多地关注"停止触发器失败".
- 了解触发失败的神经机制对于完善抑制评估至关重要.
研究的目的:
- 通过基于模型的神经科学方法来研究阻断触发器失败背后的神经机制.
- 检查触发器故障概率和fMRI信号在停止信号任务中的变化之间的关系.
- 为了确定触发器失败是否与特定的大脑区域有关,特别是在前额外下体超直接通路内.
主要方法:
- 利用了一个大型的,开放的功能磁共振成像 (fMRI) 数据集.
- 分析了113名健康成年人执行停止信号任务的数据.
- 采用基于模型的神经科学方法,将fMRI信号与停止触发器故障和SSRT联系起来.
主要成果:
- 停止触发器故障与停止失败期间黑色物质活动减少有关.
- 在成功的抑制过程中,当触发器发生故障时,观察到亚thalamic核 (STN) 的活性较低.
- 停止触发器失败与SSRT有很强的相关性,但SSRT与停止相关的fMRI信号有很弱的相关性.
结论:
- 停止过程的可靠性,而不是它的延迟 (SSRT),取决于前额外下体的超直径路径.
- 停止触发器失败可能源于不充分的黑色物质内化.
- 评估停止信号相关性的缺陷可能是不可靠的停止过程触发的基础.
更多相关视频
08:55Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
Published on: February 8, 2018
9.3K
09:52Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
9.3K
相关概念视频
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
01:28Depolarizing Blockers: Mechanism of Action
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...